Izidoro, M.S., Sokabe, M., Villa, N. Merrick, W. C., and Fraser, C. S. Human eukaryotic initiation factor 4E (eIF4E) and the nucleotide-bound state of eIF4A regulate eIF4F binding to RNA. J. Biol. Chem. 2022 Aug 11;298(10):102368. Online ahead of print.

Lapointe, C. P., Grosely, R., Sokabe, M., Alvarado, C., Wang, J., Montabana, E., Villa, N., Shin, B. S. Dever, T. E., Fraser, C. S., Fernandez, I. S., and Puglisi, J. D. eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. Nature. 2022 Jul;607(7917):185-190.

Querido, J. B., Sokabe, M., Kraatz, S., Gordiyenko, Y., Skehel, J. M., Fraser, C. S., and Ramakrishnan, V. Structure of a human 48S translational initiation complex. Science. 2020 Sep 4;369(6508):1220-1227.

Howard, C. M., Bearss, N., Subramaniyan, B., Tilley, A., Sridharan, S., Villa N., Fraser, C. S., and Raman, D. The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells. Front. Oncol. 2019 Apr 24;9:284.

Sokabe, M., and Fraser, C. S. Toward a Kinetic Understanding of Eukaryotic Translation. Cold Spring Harb. Perspect. Biol. 2019 Feb 1;11(2).

Avanzino, B. C., Jue, H., Miller, C. M., Cheung, E., Fuchs, G., and Fraser, C. S. Molecular mechanism of poliovirus Sabin vaccine strain attenuation. J. Biol. Chem. 2018 Oct 5;293(40):15471-15482.

Avanzino, B. C., Fuchs, G., and Fraser, C. S. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. Proc. Natl. Acad. Sci. U. S. A. 2017 Sep 5;114(36):9611-9616.

Sokabe, M., and Fraser, C. S. A helicase-independent activity of eIF4A in promoting mRNA recruitment to the human ribosome. Proc. Natl. Acad. Sci. U.S.A. 2017 Jun 13;114(24):6304-6309

Barbosa, N. M., Boldrin, P. E., Rossi, D., Yamamoto, P. A., Watanabe, T. F., Serrão, V. H., Hershey, J. W., Fraser, C. S., Valentini, S. R., and Zanelli, C. F. Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis. Amino Acids. 2016 Oct;48(10):2363-74.

Rossi, D., Barbosa, N. M., Galvão, F. C., Boldrin, P. E., Hershey, J. W., Zanelli, C. F., Fraser, C. S., and Valentini, S. R. Evidence for a negative cooperativity between eIF5A and eEF2 on binding to the ribosome. PLoS One. 2016 Apr 26;11(4):e0154205.

García-García, C., Frieda, K. L., Feoktistova, K., Fraser, C. S., and Block, S. M. Factor-Dependent Processivity in the Human eIF4A DEAD-box Helicase. Science. 2015 Jun 26;348(6242):1486-8.

Fraser, C. S. Quantitative studies of mRNA recruitment to the eukaryotic ribosome. Biochimie. 2015 Jul;114:58-71.

Sidrauski, C., Tsai, J. C., Kampmann, M., Hearn, B. R., Vedantham, P., Jaishankar, P., Sokabe, M., Mendez, A. S., Newton, W., Tang, E. L., Verschueren, E., Johnson, J. R., Krogan, N. J., Fraser, C. S., Weissman, J. S., Renslo, A. R., and Walter, P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15;4.

Sokabe, M., and Fraser, C. S. Human Eukaryotic Initiation Factor 2 (eIF2)-GTP-Met-tRNAi Ternary Complex and eIF3 Stabilize the 43S Preinitiation Complex. J. Biol. Chem. 2014 Nov 14;289(46):31827-36.

Avanzino, B. C., and Fraser, C. S. DEAD box unwinding caught in the act. Structure. 2014. Jul 8:22(7):931-2.

Özeş, A. R., Feoktistova, K., Avanzino, B. C., Baldwin, E. P., and Fraser, C. S. Real-time fluorescence assays to monitor duplex unwinding and ATPase activities of helicase proteins. Nature Protoc. 2014 Jun 19;9(7):1645-61.

Andaya, A., Villa, N. Jia, W., Fraser, C. S., and Leary, J. Phosphorylation stoichiometries of human eukaryotic initiation factors. Int. J. Mol. Sci. 2014 Jun 27:15(7):11523-38.

Villa, N., Do, A., Hershey, J. W., and Fraser, C. S. Human eukaryotic initiation factor 4G (eIF4G) binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. J Biol Chem. 2013 Nov 15;288(46):32932-40.

Feoktistova, K., Tuvshintogs, E., Do, A., and Fraser, C. S. Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc Natl Acad Sci U S A. 2013 110 (33) 13339-13344.

Virgili G, Frank F, Feoktistova K, Sawicki M, Sonenberg N, Fraser CS, Nagar B. Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A. Structure. 2013 Apr 2;21(4):517-27.

Sokabe, M., Fraser, C. S., and Hershey, J. W. The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit. Nucleic Acids Res. 2012 Jan;40(2):905-13.

Sun C, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser CS, Doudna JA, Nogales E, Cate J. H. Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20473-8.

Andaya, A., Jia, W., Sokabe, M., Fraser, C. S., Hershey, J. W., and Leary, J.A. Phosphorylation of human eukaryotic initiation factor 2: Novel site identification and targeted PKC involvement. J. Proteome Res. 2011 Oct 7;10(10):4613-23.

Özeş, A. R., Feoktistova, K., Avanzino, B. C., and Fraser, C. S. Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B. J Mol Biol. 2011 Sep 30;412(4):674-87.

Park, J. H., Dias, C., Lee, S. B., Valentini, S., Sokabe, M., Fraser, C. S., and Park, M. H. Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes. Protein Eng. Des. Sel. 2011 Mar;24(3):301-9.

Lindqvist, L., Robert, F., Merrick, W., Kakeya, H., Fraser, C., Osada, H., and Pelletier, J. Inhibition of translation by cytotrienin A–a member of the ansamycin family. RNA 2010 Dec;16(12):2404-13.

Lee, S. B., Park, J. H., Folk, J. E., Deck, J.A., Pegg, A. E., Sokabe, M., Fraser, C. S., and Park, M.H. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). Biochem J. 2010 Dec 15;433(1):205-13.

Fraser, C. S. The Molecular Basis of Translational Control. In John W. B. Hershey, editor: Progress in Molecular Biology and Translational Science, Vol. 90, Elsevier Press, 2009, pp. 1-51.

Fraser, C. S., Hershey, J. W., and Doudna, J. A. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat. Struct. Mol. Biol. 2009 Apr;16(4):397-404.

Zhou, M., Sandercock, A. M., Fraser, C. S., Ridlova, G., Stephens, E, Schenauer, M. R., Yokoi-Fong, T., Barsky, D., Leary, J. A., Hershey, J. W., Doudna, J. A., and Robinson, C. V. Mass Spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc. Natl. Acad. Sci. U S A. 2008 Nov 25;105(47): 18139-44.

Pöyry, T. A. A., Kaminski, A., Connell, E., Fraser, C. S., and Jackson, R. J. The mechanism of an exceptional case of reinitiation after translation of a long open-reading frame reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev. 2007 Dec 1;21(23):3149-62.

Fraser, C. S., Berry, K. E., Hershey, J. W., and Doudna, J. A. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol. Cell. 2007 Jun 22;26(6):811-9.

Fraser, C. S., and Doudna, J. A. Quantitative studies of ribosome conformational dynamics. Q. Rev. Biophys. 2007 May;40(2):163-89.

Damoc, E., Fraser, C. S., Zhou, M., Videler, H., Mayeur, G. L., Hershey, J. W., Doudna, J. A., Robinson, C. V., and Leary, J. A. Structural Characterization of the Human Eukaryotic Initiation Factor 3 Protein Complex by Mass Spectrometry. Mol. Cell Proteomics. 2007 Jul;6(7):1135-1146. Epub 2007 Feb 23.

Fraser, C. S., and Doudna, J. A. Structural and mechanistic insights into Hepatitis C viral translation initiation. Nat. Rev. Microbiol. 2007 Jan;5(1):29-38.

Siridechadilok, B., Fraser, C. S., Hall, R. J., Doudna, J. A., and Nogales, E. Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis. Science. 2005 Dec 2;310(5753):1513-5.

Fraser, C. S., and Hershey, J. W. B. Movement in Ribosome Translocation. J. Biol. 2005, 4:8

Ji, H., Fraser, C. S., Yu, Y., Leary, J., and Doudna, J. A. Coordinated assembly of human translation initiation complexes by the Hepatitis C Virus internal ribosome entry site RNA. Proc. Natl. Acad. Sci. U. S. A. 2004 Dec 7;101(49):16990-5.

Fraser, C. S., Lee, J. Y., Mayeur, G. L., Bushell, M., Doudna, J. A., and Hershey, J. W. B. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40S ribosomal subunits in vitro. J. Biol. Chem. 2004 Mar 5;279(10):8946-56.

Mayeur, G. L., Fraser, C. S., Pieretti, F., Block, K. L., and Hershey, J. W. B. Characterization of eIF3k, a newly discovered subunit of mammalian translation initiation factor eIF3. Eur. J. Biochem. 2003 Oct 15; 270(20): 4133-4139.

Daughenbaugh, K. F., Fraser, C. S., Hershey, J. W. B., and Hardy, M. E. The genome-linked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment. EMBO J. 2003 Jun 2;22(11):2852-9.

Fraser, C. S., Pain, V. M., and Morley, S. J. Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein. Biochem. J. 1999 Sep 15; 342 Pt 3:519-26.

Fraser, C. S., Pain, V. M., and Morley, S. J. The association of initiation factor 4F with poly(A)-binding protein is enhanced in serum-stimulated Xenopus kidney cells. J. Biol. Chem. 1999 Jan 1; 274(1):196-204.